The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro

Title:	The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro
Authors:	Jussi Sarin Leena Bjorkvik Markus Hiltunen Leena Hupa Jaakko Pulkkinen Pekka K. Vallittu
Keywords:	Bioactive glass;S53P4;Fibrin sealant;Fibrin glue
Issue Date:	2016
Publisher:	ĐHQGHN
Abstract:	Fibrin glue, a two-component tissue adhesive, has a range of clinical indications. Bioactive glass (BG) S53P4 has been approved for clinical use in several craniomaxillofacial and orthopedic applications. Although sometimes used simultaneously, there is no data available regarding the possible interaction of these two biocompatible substances. In this in vitro study, using a BG particle concentration of 4 mg/ml, a 0.4 unit pH increment (p < 0.001) was observed in simulated body fluid (SBF) after a 7-day incubation period. The addition of fibrin glue (0.13 g, SD 0.04; or 3.7 mg/ml) on top of the BG particles raised further the pH by 0.5 units (p < 0.001). The difference between these groups was statistically significant (p = 0.008). With a BG concentration of 25 mg/ml and a fibrin glue concentration of 18 mg/ml during a 14-day incubation period, a pH increment of 0.6 units and SBF ion concentration change of Ca, K, Mg, Na, P and Si ions was seen. Moreover, a penetration depth between 4 and 6 mm was observed when fibrin glue was applied on top of a bed of BG particles. Conclusions: Fibrin glue is not likely to have a distracting effect on BG-induced pH increase of the SBF although it might delay early BG surface reactions based on ion concentration measurements. Fibrin glue penetrated to the interparticle space to some extent, binding the particles together for easy clinical use of BG.
Description:	p. 482-487
URI:	http://repository.vnu.edu.vn/handle/VNU_123/58303
ISSN:	2468-2284
Appears in Collections:	Advanced Materials and Devices